反应详情

温度

50 °C

A solution of 4-(4-isothiocyanato-4-methylpiperidin-1-yl)-6-methylpyrimidine (1.18 g, 0.53 mmol) in ammonia (7 M in MeOH, 13.6 mL, 95.0 mmol) was stirred in a sealed tube at room temperature for 3 h and then heated at 50° C. for 18 h. After cooling to room temperature the mixture was evaporated. Purification by chromatography (silica gel, 50 g, 0 to 20% methanol in dichloromethane) afforded the title compound (1.2 g, 100%) as a white foam.

1. temperatureAfter cooling to room temperature the mixture
2. customwas evaporated
3. customPurification by chromatography (silica gel, 50 g, 0 to 20% methanol in dichloromethane)