4-Chloro-6-methylpyrimidine → HCID 58397917, compound

HRID 451552Notes

Reaction equation

HRID 451552 reaction equation
Cl[C:2]1[CH:7]=[C:6]([CH3:8])[N:5]=[CH:4][N:3]=1.[F:9][C:10]1[CH:11]=[C:12]([C:17]2[C:18]3[N:19]([N:23]=[C:24]([NH:26][CH:27]4[CH2:32][CH2:31][NH:30][CH:29]([CH3:33])[CH2:28]4)[N:25]=3)[CH:20]=[CH:21][CH:22]=2)[CH:13]=[CH:14][C:15]=1[F:16]>>[F:9][C:10]1[CH:11]=[C:12]([C:17]2[C:18]3[N:19]([N:23]=[C:24]([NH:26][CH:27]4[CH2:32][CH2:31][N:30]([C:2]5[CH:7]=[C:6]([CH3:8])[N:5]=[CH:4][N:3]=5)[CH:29]([CH3:33])[CH2:28]4)[N:25]=3)[CH:20]=[CH:21][CH:22]=2)[CH:13]=[CH:14][C:15]=1[F:16]

Participants

3

Reactant 2

HCID 5817964-Chloro-6-methylpyrimidineHCID 67342790HCID 67342790, compound

Product 1

HCID 58397917HCID 58397917, compound

Procedure

Prepared in analogy to example 57c) employing 4-chloro-6-methylpyrimidine instead of 4-bromo-2-methylpyridine and 8-(3,4-difluorophenyl)-N-(2-methylpiperidin-4-yl)-[1,2,4]triazolo[1,5-a]pyridin-2-amine instead of 8-(2-chloro-4-fluorophenyl)-N-(piperidin-4-yl)-[1,2,4]triazolo[1,5-a]pyridin-2-amine. The title compound was obtained as a light brown foam.

Workup

  1. customPrepared in analogy to example 57c)

Sources & evidence

ORD record
ord-5eeb28129acd44db9350996f3bd86dc7
Source dataset
uspto-grants-2013_07
Patent number
US08486967B2

Reaction notes

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