Methanol → HCID 67342673, compound

Participants

Reaction Steps

Prepared in analogy to example 219f), starting from (2-amino-[1,2,4]triazolo[1,5-a]pyridin-8-yl)(4-fluorophenyl)methanol and 1-(3-methyl-1,2,4-thiadiazol-5-yl)piperidin-4-one. As a reducing agent 1 eq decaborane in methanol was used at 50° C. over night. The crude product was purified by column chromatography on silica gel using a gradient from CH2Cl2 to CH2Cl2/MeOH 19:1 (v/v) as eluent to yield eluting first {8-[(4-fluoro-phenyl)-methoxy-methyl]-[1,2,4]triazolo[1,5-a]pyridin-2-yl}-[1-(3-methyl-[1,2,4]thiadiazol-5-yl)-piperidin-4-yl]-amine (yield: 4%) as a colorless oil.

Provenance & Evidence