HCID 86656222, compound → HCID 67336520, compound

HRID 451572Notes

Reaction equation

HRID 451572 reaction equation
C[O:2][C:3](=O)[CH:4]([C:17]1[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=1)[O:5][CH2:6][CH2:7][NH:8][NH:9]C(OC(C)(C)C)=O>O>[NH2:9][N:8]1[CH2:7][CH2:6][O:5][CH:4]([C:17]2[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=2)[C:3]1=[O:2]

Participants

3

Reactant 1

HCID 86656222HCID 86656222, compound

Product 1

HCID 67336520HCID 67336520, compoundYield 79.3%

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

tert-Butyl 2-(2-(2-methoxy-2-oxo-1-phenylethoxy)ethyl)hydrazinecarboxylate (390 mg, 1.2 mmol) in water (85 mL) was heated to 95° C. for 12 h. The reaction mixture was extracted with dichloromethane, the organic layers were combined, dried over Na2SO4 and the solvent was evaporated to give the title compound as light yellow oil (183 mg, 79%).

Workup

  1. extractionThe reaction mixture was extracted with dichloromethane
  2. dry with materialdried over Na2SO4
  3. customthe solvent was evaporated

Sources & evidence

ORD record
ord-e3e877cfe7aa4337892b9df04da43635
Source dataset
uspto-grants-2013_07
Patent number
US08486967B2

Reaction notes

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