1-(3-Methyl-1,2,4-thiadiazol-5-yl)piperidin-4-one → HCID 58398054, compound

HRID 451574Notes

Reaction equation

HRID 451574 reaction equation
[C:1]1([CH:7]2[C:12]3=[N:13][C:14]([NH2:16])=[N:15][N:11]3[CH2:10][CH2:9][O:8]2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[CH3:17][C:18]1[N:22]=[C:21]([N:23]2[CH2:28][CH2:27][C:26](=O)[CH2:25][CH2:24]2)[S:20][N:19]=1>>[CH3:17][C:18]1[N:22]=[C:21]([N:23]2[CH2:24][CH2:25][CH:26]([NH:16][C:14]3[N:13]=[C:12]4[CH:7]([C:1]5[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=5)[O:8][CH2:9][CH2:10][N:11]4[N:15]=3)[CH2:27][CH2:28]2)[S:20][N:19]=1

Participants

3

Reactant 2

HCID 592585101-(3-Methyl-1,2,4-thiadiazol-5-yl)piperidin-4-oneHCID 67335701HCID 67335701, compound

Product 1

HCID 58398054HCID 58398054, compound

Procedure

Prepared in analogy to example 261a employing 8-phenyl-6,8-dihydro-5H-[1,2,4]triazolo[5,1-c][1,4]oxazin-2-amine and 1-(3-methyl-1,2,4-thiadiazol-5-yl)piperidin-4-one (see example 1d). The title compound was obtained as an white foam.

Workup

  1. customPrepared in analogy to example 261a

Sources & evidence

ORD record
ord-9f74afe4b1b5416d8ae07a77c5036e53
Source dataset
uspto-grants-2013_07
Patent number
US08486967B2

Reaction notes

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