反应详情

温度

95 °C

1-(4-tert-Butylphenyl)-3-chloro-1-propanone (22.25 g, 99 mmol) was dissolved in concentrated sulfuric acid (100 ml) and heated on a water bath at 95° C. for 2.5 hours. The reaction mixture was cooled, poured onto ice, and extracted with diethyl ether. The combined organic extracts were washed with saturated aqueous sodium bicarbonate, dried with magnesium sulfate, and the filtrate was evaporated under reduced pressure to provide the title compound which was used without further purification in the next step.

1. temperatureThe reaction mixture was cooled
2. additionpoured onto ice
3. extractionextracted with diethyl ether
4. washThe combined organic extracts were washed with saturated aqueous sodium bicarbonate
5. dry with materialdried with magnesium sulfate
6. customthe filtrate was evaporated under reduced pressure