Hydrochloric Acid → HCID 10241787, compound

Participants

Reaction Steps

1.9 g of 2-isopropyl-5-methyl-bicyclo[4.1.0]heptane-7-carboxylic acid ethyl ester (66%) from synthesis example 1a are boiled under reflux for 3 hours with 20 ml of 10% sodium hydroxide solution. 25 ml of 10% hydrochloric acid are added and the mixture is extracted twice with 50 ml of diethyl ether. The organic phases are dried with sodium sulfate and the solvent is distilled off under vacuum. 1.37 g of a crude product containing 69% of the 2-isopropyl-5-methyl-bicyclo[4.1.0]heptane-7-carboxylic acid isomers are obtained.

Provenance & Evidence