HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 45168Generated: October 29, 2026
5-Hydroxyindole → HCID 59394040, compound
https://huagongshe.com/reaction/45168
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | 5-Hydroxyindole | HCID 16054 | — |
| Reactant | 1,8-Diazabicyclo(5.4.0)undec-7-ene | HCID 81184 | — |
| Reactant | HCID 59394014 | HCID 59394014 | — |
| Solvent | Acetonitrile | HCID 6342 | — |
| Product | HCID 59394040 | HCID 59394040 | — |
Reaction Steps
To a solution of 4-chloro-5,8-dihydro-6H-pyrido[3,4-d]pyrimidine-6,7-dicarboxylic acid 7-tert-butyl ester 6-ethyl ester (1 g, 2.93 mmol) in CH3CN (30 mL), 5-hydroxy-indole (0.779 g, 5.85 mmol) and DBU (0.88 mL, 5.85 mmol) are added. After heating at 60° C. for 5 h the reaction is evaporated and the product isolated using FCC eluting with heptane:EtOAc 1:1. MS (ESI) m/z 439.1 (M+1).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08541432B2 |
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| Source dataset | uspto-grants-2013_09 |
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| ORD ID | ord-a93611705c9d4d5fa70f48def90e0641 |
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| Source note | uspto-grants-2013_09 |
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