Methylamine ethanol → HCID 178485053, compound

HRID 451709Notes

Reaction equation

HRID 451709 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([C@H:8]([O:22][CH2:23][CH2:24][NH:25][C:26](=[N:29][C:30]#[N:31])SC)[C@@H:9]2[CH2:14][CH2:13][CH2:12][N:11]([C:15]([O:17][C:18]([CH3:21])([CH3:20])[CH3:19])=[O:16])[CH2:10]2)[CH:5]=[CH:6][CH:7]=1.[CH3:32][NH2:33].CCO>>[Cl:1][C:2]1[CH:3]=[C:4]([C@H:8]([O:22][CH2:23][CH2:24][NH:25][C:26]([NH:33][CH3:32])=[N:29][C:30]#[N:31])[C@@H:9]2[CH2:14][CH2:13][CH2:12][N:11]([C:15]([O:17][C:18]([CH3:21])([CH3:20])[CH3:19])=[O:16])[CH2:10]2)[CH:5]=[CH:6][CH:7]=1

Participants

3

Reactant 2

HCID 22028356Methylamine ethanolHCID 178503925HCID 178503925, compound

Product 1

HCID 178485053HCID 178485053, compound

Procedure

A 100 mL flask was charged with (R)-tert-butyl 3-((R)-(3-chlorophenyl)(2-((cyanoimino)(methylthio)methylamino)ethoxy)methyl)piperidine-1-carboxylate (2.2 g, 4.72 mmol) dissolved in 50 mL MeNH2/EtOH solution and stirred overnight. The mixture was concentrated in vacuo and used without any further purification.

Workup

  1. concentrationThe mixture was concentrated in vacuo
  2. customused without any further purification

Sources & evidence

ORD record
ord-88f27e0600fe417a924d0a329c4ebb2f
Source dataset
uspto-grants-2013_07
Patent number
US08487108B2

Reaction notes

Loading…