Benzyl Alcohol → HCID 21127829, compound

HRID 45176Notes

Reaction equation

HRID 45176 reaction equation
[CH:1]12[O:10][CH:7]([CH2:8][CH2:9]1)[CH:6]1[CH:2]2[C:3](=[O:12])[O:4][C:5]1=[O:11].[CH2:13]([OH:20])[C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1>O1CCOCC1>[CH2:13]([O:20][C:5]([CH:6]1[CH:2]([C:3]([OH:12])=[O:4])[CH:1]2[O:10][CH:7]1[CH2:8][CH2:9]2)=[O:11])[C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1

Participants

4

Reactant 2

HCID 244Benzyl AlcoholHCID 930044,7-Epoxyisobenzofuran-1,3-dione, hexahydro-

Product 1

HCID 21127829HCID 21127829, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Conditions

Temperature
80 °C

Procedure

A mixture of 4,10-dioxa-tricyclo[5.2.1.02,6]decane-3,5-dione (8, 3.7 g, 22.0 mmol) and benzyl alcohol (9) (4.5 mL, 44.0 mmol) in dioxane was heated at 80° C. for 16 h. Cooled to room temperature and evaporated to remove solvent. Residue obtained was triturated with diisopropyl ether (20 mL) to give white solid of 10 which was filtered, washed with diisopropyl ether (10 mL) and dried. Yield: 3.6 g (59%). 1H NMR (300 MHz, CDCl3) δ 1.45-1.55 (m, 2H); 1.78-1.81 (m, 2H); 3.05 (s, 2H); 4.91 (d, J=9.4 Hz, 2H); 5.02 (d, J=6.3 Hz, 1H); 5.13 (d, J=6.3 Hz, 1H); 7.28-7.40 (m, 5H).

Workup

  1. temperatureCooled to room temperature
  2. customevaporated
  3. customto remove solvent
  4. customResidue obtained
  5. customwas triturated with diisopropyl ether (20 mL)

Sources & evidence

ORD record
ord-0cf245b8961f43a7bd6dd9c2976f4069
Source dataset
uspto-grants-2013_09
Patent number
US08541458B2

Reaction notes

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