Methanol → HCID 68711075, compound

Participants

Reaction Steps

A 250 mL round bottom flask was charged with 0.2479 g (0.54 mmol) of (S)-tert-butyl 1-(N-methyl-N-(2-(trimethylsilyl)ethoxycarbonyl)amino)-3-(4-methylcyclohexyl)propan-2-ylcarbamate, 0.2784 g of 10% Pd/C, and 20 mL of MeOH. The reaction mixture was stirred at rt under a balloon of hydrogen for 5 h. The mixture was then filtered through filter agent, Celite® 545, washed with MeOH. The filtrate was evaporated under reduced pressure to afford 0.1799 g (100%) of 2-(trimethylsilyl)ethyl 2-amino-3-(1-methylcyclohexyl)propyl(methyl)carbamate, which was used in the next step without further purification. MS ESI +ve m/z 329 (M+H).

Provenance & Evidence