HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 451798Generated: October 27, 2026
Methylamine → Benzyl 1-(bicyclo[2.2.2]octan-1-yl)-3-(methylamino)propan-2-ylcarbamate
https://huagongshe.com/reaction/451798
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Methylamine | HCID 6329 | — |
| Reactant | 2-(Benzyloxycarbonylamino)-3-(bicyclo[2.2.2]octan-1-yl)propyl methanesulfonate | HCID 59201441 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | Benzyl 1-(bicyclo[2.2.2]octan-1-yl)-3-(methylamino)propan-2-ylcarbamate | HCID 59201448 | — |
Reaction Steps
2-(benzyloxycarbonylamino)-3-(bicyclo[2.2.2]octan-1-yl)propyl methanesulfonate (830 mg, 2.1 mmol) was dissolved in 15 mL of NH2Me in MeOH and stirred at 30-40° C. overnight. The mixture was concentrated to give benzyl 1-(bicyclo[2.2.2]octan-1-yl)-3-(methylamino)propan-2-ylcarbamate (1.0 g, crude) as an oil, which was used in the next step without further purification. MS ESI +ve m/z 331 (M+H).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08487108B2 |
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| Source dataset | uspto-grants-2013_07 |
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| ORD ID | ord-3c61f87e1cd34585b2a77984a0b00d05 |
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| Source note | uspto-grants-2013_07 |
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