HCID 59201410, compound → HCID 59201535, compound

Participants

Reaction Steps

A mixture of benzyl 1-(bicyclo[2.2.2]octan-1-yl)-3-(N-methyl-N-tert-butoxycarbonylamino)propan-2-ylcarbamate (250 mg, 0.58 mmol) and Pd(OH)2 (20%, 60 mg) in 12 Ml of absolute of MeOH was hydrogenated under 20 psi H2 for 2 h. TLC (EtOAc/Petroleum ether=1:2) indicated the completion of reaction. The mixture was then filtered and evaporated to afford tert-butyl 2-amino-3-(bicyclo[2.2.2]octan-1-yl)propyl(methyl)carbamate (150 mg, 87%) as oil, which was used in the next step without further purification.

Provenance & Evidence