HRID451834

反应详情

EQUATION

反应方程式

REACTANTS

反应物

结构：CN(C(=O)OC(C)(C)C)[C@H](CN=[N+]=[N-])C[C@@H]1CCCCOC1

HCID86639454

未命名化合物

PRODUCTS

生成物

结构：CC(C)(C)OC(=O)N[C@H](CN)C[C@@H]1CCCCOC1

HCID86639453

未命名化合物

收率 96%

AUXILIARIES

试剂、催化剂与溶剂

催化剂HCID23938

Palladium

溶剂HCID887

Methanol

CH4O

PROCEDURE

实验过程

Above tert-butyl (S)-1-azido-3-((S)-oxepan-3-yl)propan-2-yl(methyl)carbamate was hydrogenated under H2 (40 psi), catalyzed by 10% Pd/C, in MeOH for 1 h. The catalyst was filtered off and concentrated to give tert-butyl (S)-1-amino-3-((S)-oxepan-3-yl)propan-2-ylcarbamate (76.8 mg, 96% over 2 steps). MS ESI +ve m/z 287 (M+H).

WORKUP

后处理

filtrationThe catalyst was filtered off
concentrationconcentrated