HCID 58017434, compound → 2-Amino-3-(oxan-3-yl)propan-1-ol

To the solution of (2S)-2-hydrazinyl-3-(tetrahydro-2H-pyran-3-yl)propan-1-ol (5.79 g, 0.033 mol) in MeOH (100 mL) was added Raney Ni. The flask was degassed and equipped with a hydrogen inflated balloon. The flask was dipped into an ultrasound bath filled with water and sonicated for 4 hr at rt until the starting material was completely consumed. The mixture was then filtered through celite, and the filter cake was washed with MeOH (2×30 mL). Removal under reduced pressure gave (2S)-2-amino-3-(tetrahydro-2H-pyran-3-yl)propan-1-ol (5.4 g, 90%).

1. customThe flask was degassed
2. customequipped with a hydrogen inflated balloon
3. customThe flask was dipped into an ultrasound bath
4. additionfilled with water
5. customsonicated for 4 hr at rt until the starting material
6. customwas completely consumed
7. filtrationThe mixture was then filtered through celite
8. washthe filter cake was washed with MeOH (2×30 mL)
9. customRemoval under reduced pressure

ORD record

ord-c4c015bc6501412cb877396c4ede027d

Source dataset

uspto-grants-2013_07

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US08487108B2