HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 451895Generated: October 25, 2026
Triethylammonium formate → HCID 59201404, compound
https://huagongshe.com/reaction/451895
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Triethylammonium formate | HCID 11084032 | — |
| Reactant | methyl 2-((R)-(3-chlorophenyl)((R)-1-((S)-5,5-dimethyl-1-(N-methyl-N-(2-trimethylsilylethoxycarbonyl)amino)hexan-2-ylcarbamoyl)piperidin-3-yl)methoxy)ethylcarbamate | HCID 68709121 | — |
| Solvent | Acetonitrile | HCID 6342 | — |
| Product | HCID 59201404 | HCID 59201404 | — |
Reaction Steps
Methyl 2-((R)-(3-chlorophenyl)((R)-1-((S)-5,5-dimethyl-1-(N-methyl-N-(2-trimethylsilylethoxycarbonyl)amino)hexan-2-ylcarbamoyl)piperidin-3-yl)methoxy)ethylcarbamate was dissolved in CH3CN and treated with 75 mg (0.504 mmol, 4.5 equiv) of TEAF and the mixture heated to 55° C. for 3 h. The solution was evaporated and purified by prep HPLC to afford methyl 2-((R)-(3-chlorophenyl)((R)-1-((S)-5,5-dimethyl-1-(methylamino)hexan-2-ylcarbamoyl)piperidin-3-yl)methoxy)ethylcarbamate.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08487108B2 |
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| Source dataset | uspto-grants-2013_07 |
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| ORD ID | ord-d2c0f47d327845d184ac67fa682a2889 |
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| Source note | uspto-grants-2013_07 |
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