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HRID451901

反应详情

EQUATION

反应方程式

HRID 451901 的结构方程式

REACTANTS

反应物

1
反应SMILES：COC(=O)NCCO[C@@H](c1cccc(Cl)c1)[C@@H]1CCCN(C(=NC#N)N[C@@H](CC2CCCCC2)CN(C)C(=O)OC(C)(C)C)C1
HCID178502137

未命名化合物

PRODUCTS

产物

1
反应SMILES：CNC[C@H](CC1CCCCC1)NC(=NC#N)N1CCC[C@@H]([C@@H](OCCNC(=O)OC)c2cccc(Cl)c2)C1
HCID178484172

未命名化合物

收率 59%

AUXILIARIES

试剂、催化剂与溶剂

1
反应SMILES：C1COCCO1.Cl
溶剂HCID20443148

1,4-Dioxane hydrochloride

C4H9ClO2

PROCEDURE

实验过程

The methyl 2-((R)-(3-chlorophenyl)((R)-1-(N′-cyano-N—((S)-1-cyclohexyl-3-(N-methyl-N-(tert-butoxycarbonyl)amino)propan-2-yl)carbamimidoyl)piperidin-3-yl)methoxy)ethylcarbamate (8 mg, 0.0124 mmol) was dissolved in a solution of 4 N HCl/dioxane (5 mL). The reaction mixture was stirred at rt for 1 h and then concentrated in vacuo. The residue was purified by preparative HPLC to afford the product (4 mg, 59%).

WORKUP

后处理

  1. concentrationconcentrated in vacuo
  2. customThe residue was purified by preparative HPLC