HCID 58017394, compound → HCID 58017383, compound

HRID 452016Notes

Reaction equation

HRID 452016 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([C@@H:9]([C@@H:18]2[CH2:23][CH2:22][CH2:21][N:20]([C:24](=[O:37])[NH:25][C@@H:26]([CH2:30][C@@H:31]3[CH2:36][CH2:35][CH2:34][O:33][CH2:32]3)[CH2:27][NH:28][CH3:29])[CH2:19]2)[O:10][CH2:11][CH2:12][NH:13][C:14](=[O:17])[O:15][CH3:16])[CH:5]=[C:6]([F:8])[CH:7]=1.ClC1C=C([C@@H]([C@@H]2CCCN(C(=O)N[C@H](CC3CCCOC3)CNC)C2)OCCNC(=O)OC)C=C(F)C=1>>[Cl:1][C:2]1[CH:3]=[C:4]([C@@H:9]([C@@H:18]2[CH2:23][CH2:22][CH2:21][N:20]([C:24](=[O:37])[NH:25][C@@H:26]([CH2:30][C@H:31]3[CH2:36][CH2:35][CH2:34][O:33][CH2:32]3)[CH2:27][NH:28][CH3:29])[CH2:19]2)[O:10][CH2:11][CH2:12][NH:13][C:14](=[O:17])[O:15][CH3:16])[CH:5]=[C:6]([F:8])[CH:7]=1

Participants

3

Reactant 2

HCID 58017394HCID 58017394, compoundHCID 58017421HCID 58017421, compound2×

Product 1

HCID 58017383HCID 58017383, compound

Procedure

The methyl 2-((R)-(3-chloro-5-fluorophenyl)((R)-1-((S)-1-(methylamino)-3-((S)-tetrahydro-2H-pyran-3-yl)propan-2-ylcarbamoyl)piperidin-3-yl)methoxy)ethylcarbamate, methyl 2-((R)-(3-chloro-5-fluorophenyl)((3R)-1-((R)-1-(methylamino)-3-(tetrahydro-2H-pyran-3-yl)propan-2-ylcarbamoyl)piperidin-3-yl)methoxy)ethylcarbamate Isomer 1, and methyl 2-((R)-(3-chloro-5-fluorophenyl)((3R)-1-((R)-1-(methylamino)-3-(tetrahydro-2H-pyran-3-yl)propan-2-ylcarbamoyl)piperidin-3-yl)methoxy)ethylcarbamate Isomer 2 was prepared as above.

Sources & evidence

ORD record
ord-28368aff3e964d0e8abd126605c9a34e
Source dataset
uspto-grants-2013_07
Patent number
US08487108B2

Reaction notes

Loading…