Fumaric Acid → HCID 67363982, compound

Participants

Reaction Steps

An ethanol solution of methyl 2-((R)-(3-fluorophenyl)((R)-1-((S)-1-(methylamino)-3-((S)-tetrahydro-2H-pyran-3-yl)propan-2-yl carbamoyl)piperidin-3-yl)methoxy)ethylcarbamate (87.2 mg, 0.17 mmol) was treated with fumaric acid (19.8 mg, 0.17 mmol). The solvent was removed in vacuo and the residue re-dissolved in water. The solution was frozen using a dry ice-acetone bath and placed on a lypholizer to afford methyl 2-((R)-(3-fluorophenyl)((R)-1-((S)-1-(methylamino)-3-((S)-tetrahydro-2H-pyran-3-yl)propan-2-ylcarbamoyl)piperidin-3-yl)methoxy)ethylcarbamate fumaric acid salt (106.8 mg) as a white solid.

Provenance & Evidence