HuagongsheHuagongshe Chemistry Print Report · For research reference only
2,6-Dichlorobenzaldehyde → HCID 178517681, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2,6-Dichlorobenzaldehyde | HCID 6737 | — |
| Reactant | 5-Aminobenzimidazole | HCID 13623 | — |
| Reactant | 1,1'-Carbonyldiimidazole | HCID 68263 | — |
| Reactant | Trimethylsilyl cyanide | HCID 82115 | — |
| Reactant | Trifluoroacetate | HCID 84468 | — |
| Product | HCID 178517681 | HCID 178517681 | — |
Reaction Steps
The compound was synthesized as trifluoroacetate salt starting from 5-aminobenzimidazole (0.585 g, 4.4 mmol), 2,6-dichloro-benzaldehyde (0.7 g, 4 mmol), TMSCN (0.5 mL, 4 mmol), PdC (10%, 0.02 g), TEA (0.4 mL, 2.8 mmol), di-(imidazol-1-yl)methanone (0.253 g, 1.56 mmol) as described in method 2. The product was purified by means of preparative HPLC.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08486940B2 |
| Source dataset | uspto-grants-2013_07 |
| ORD ID | ord-58ca1a7694404dd2b1fe4c16e14f6d54 |
| Source note | uspto-grants-2013_07 |