HuagongsheHuagongshe Chemistry Print Report · For research reference only
7-Chloro-6-fluoro-1-methoxyisoquinoline → 1-[3-(7-Chloro-1-methoxyisoquinolin-6-yloxy)-cyclobutyl]-1-(4-fluorophenyl)-propylamine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 7-Chloro-6-fluoro-1-methoxyisoquinoline | HCID 58380828 | — |
| Reactant | 1-[4-(7-Chloro-1-methoxyisoquinolin-6-yloxy)-cyclohexyl]-1-(4-methoxyphenyl)-ethylamine | HCID 58380981 | — |
| Reactant | 1-(1-Aminopropyl)-1-(4-fluorophenyl)cyclobutan-3-ol | HCID 58381040 | — |
| Product | 1-[3-(7-Chloro-1-methoxyisoquinolin-6-yloxy)-cyclobutyl]-1-(4-fluorophenyl)-propylamine | HCID 67075681 | — |
Reaction Steps
1-[3-(7-chloro-1-methoxyisoquinolin-6-yloxy)-cyclobutyl]-1-(4-fluorophenyl)-propylamine (2 isomeric mixtures) were prepared from 1-(1-aminopropyl)-1-(4-fluorophenyl)cyclobutan-3-ol (114) and 7-chloro-6-fluoro-1-methoxyisoquinoline (10) as described for (109). The two stereoisomers could be separated by silica gel chromatography, relative stereochemistry was not assigned.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08541449B2 |
| Source dataset | uspto-grants-2013_09 |
| ORD ID | ord-12f10541b97c4847839b4de813642ef4 |
| Source note | uspto-grants-2013_09 |