HuagongsheHuagongshe Chemistry Print Report · For research reference only
1,2-Diaminocyclohexane → (S)-3-(1H-benzo[d]imidazol-5-yl)-4-isopropyloxazolidin-2-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1,2-Diaminocyclohexane | HCID 4610 | — |
| Reactant | Cesium fluoride | HCID 25953 | — |
| Reactant | Ethyl orthoformate | HCID 31214 | — |
| Reactant | (4S)-4-(propan-2-yl)-1,3-oxazolidin-2-one | HCID 7157133 | — |
| Reactant | 4-Iodobenzene-1,2-diamine | HCID 11207049 | — |
| Catalyst | Copper(1+) iodide; Copper(I) iodide; Cuprous iodide; Cuprous iodide (CuI) | HCID 24350 | — |
| Product | (S)-3-(1H-benzo[d]imidazol-5-yl)-4-isopropyloxazolidin-2-one | HCID 178448157 | — |
Reaction Steps
The compound was synthesized starting from (S)-4-isopropyloxazolidin-2-one (0.065 g, 0.5 mmol), 4-iodobenzene-1,2-diamine (0.117 g, 0.5 mmol), copper(I) iodide (0.010 g, 0.05 mmol), cesium fluoride (0.276 g, 1 mmol), cyclohexane-1,2-diamine (0.006 mL, 0.05 mmol), triethyl orthoformate (3 mL) as described in method 5 step D.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08486940B2 |
| Source dataset | uspto-grants-2013_07 |
| ORD ID | ord-1d73ca016b714e09b3b2d5513c4ba371 |
| Source note | uspto-grants-2013_07 |