HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → (4S,5R)-3-(1H-benzo[d]imidazol-6-yl)-4,5-diphenyloxazolidin-2-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | 1,2-Diaminocyclohexane | HCID 4610 | — |
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | 4-Bromobenzene-1,2-diamine | HCID 323593 | — |
| Reactant | (4S,5R)-(-)-cis-4,5-Diphenyl-2-oxazolidinone | HCID 9859564 | — |
| Catalyst | Copper(1+) iodide; Copper(I) iodide; Cuprous iodide; Cuprous iodide (CuI) | HCID 24350 | — |
| Solvent | Formic Acid | HCID 284 | — |
| Product | (4S,5R)-3-(1H-benzo[d]imidazol-6-yl)-4,5-diphenyloxazolidin-2-one | HCID 58229203 | — |
Reaction Steps
The compound was synthesized starting from (4S,5R)-4,5-diphenyloxazolidin-2-one (0.479 g, 2 mmol), 4-bromobenzene-1,2-diamine (0.374 g, 2 mmol), copper(I) iodide (0.038 g, 0.2 mmol), potassium carbonate (0.553 g, 4 mmol), cyclohexane-1,2-diamine (0.024 mL, 0.2 mmol), 5N HCl (5.8 mL), formic acid (0.582 mL) as described in method 5 step D
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08486940B2 |
| Source dataset | uspto-grants-2013_07 |
| ORD ID | ord-2dd6f40eb9a14500807db04edfdf42df |
| Source note | uspto-grants-2013_07 |