Lithium Hexamethyldisilazide → HCID 178489706, compound

Participants

Reaction Steps

The compound was synthesized starting from 5 (6)-bromobenzimidazole (200 mg; 1 mmol; 1 eq.), 2-dicyclohexylphosphino-2′-(N,N-dimethylamino)biphenyl (9 mg; 0.024 mmol; 0.024 eq.; 2.4 mol %), Pd2 dba3 (9 mg; 0.01 mmol; 0.01 eq.; 1 mol %) and 2-(4-methoxybenzyl)-pyrrolidine oxalate (337 mg; 1.2 mmol; 1.2 eq.) and lithiumbis(trimethylsilyl)amide (1 M solution in THF; 3.3 ml; 3.3 mmol; 3.3 eq.); yield: 0.06 g (1.9%); MS m/z: 308.2 [M+H]+; HPLC (Gradient 3): rt 14.07 (98.9%)

Provenance & Evidence