Hydrochloric Acid → HCID 67210973, compound

Participants

Reaction Steps

Compound 53 (80 mg, 0.17 mmol) obtained in Example 53 was suspended in ethanol (2 mL), 10 mol/L aqueous sodium hydroxide solution (3.1 mL) was added, and the mixture was stirred under reflux for 3 days. Under ice-cooling, the mixture was adjusted to pH 1 with 2 mol/L hydrochloric acid, and the mixture was extracted with ethyl acetate. The organic layer was washed with brine, dried over anhydrous magnesium sulfate, and concentrated under reduced pressure. The residue was purified by silica gel column chromatography (chloroform/methanol=98/2 to 90/10) to give the title compound (compound 55) (34 mg, 41%).

Provenance & Evidence