Sodium Hydroxide → HCID 67211111, compound

Participants

Reaction Steps

[step 1] (E)-{2-[2-(2-Methoxycarbonylethyl)-4-methyl-6-phenylbenzimidazol-1-yl]methyl-10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5-ylidene}acetonitrile (350 mg, 0.65 mmol) obtained in Example 61, step 1 was dissolved in ethanol (4 mL), 2 mol/L aqueous sodium hydroxide solution (0.8 mL) was added, and the mixture was stirred at room temperature for 2 hr. The mixture was concentrated under reduced pressure, water and 2 mol/L hydrochloric acid were added, and the precipitate was collected by filtration to give (E)-[2-{2-(2-carboxyethyl)-4-methyl-6-phenylbenzimidazol-1-yl}methyl-10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5-ylidene]acetonitrile (336 mg, 99%).

Provenance & Evidence