Hydrochloric Acid → HCID 58381011, compound

Participants

Reaction Steps

A 2M aqueous solution of hydrochloric acid (3.8 mL) was added to a solution of C-[4-(1-benzyloxy-7-chloro-isoquinolin-6-yloxy)-cyclohexyl]-C-(4-methoxy-phenyl)-methylamine (36, 40 mg, 0.08 mmol) in isopropanol (4 mL). The reaction mixture was stirred overnight. Isopropanol was removed under reduced pressure and the remaining aqueous solution freeze dried to give crude product as an amorphous powder. This was treated twice with acetonitrile/water and freeze dried to give the desired product as a colourless hydrochloride salt. The relative stereochemistry was not assigned.

Provenance & Evidence