Aniline → HCID 67211557, compound

Participants

Reaction Steps

(E)-[2-(2,4-Dimethyl-6-phenylbenzimidazol-1-yl)methyl-10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5-ylidene]acetic acid (0.050 g, 0.103 mmol) obtained in Example 55 was dissolved in DMF (1 mL), aniline (0.018 mL, 0.200 mmol), 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide (0.047 g, 0.240 mmol) and 1-hydroxybenzotriazole (0.032 g, 0.240 mmol) were added, and the mixture was stirred at room temperature for 15 hr. Saturated aqueous sodium hydrogen carbonate solution was added to the mixture, and the precipitated solid was collected by suction filtration to give the title compound (compound 90) (0.048 g, 83%).

Provenance & Evidence