Hydrochloric Acid → 6-[4-(amino-phenyl-methyl)-cyclohexyloxy]-7-chloro-2H-isoquinolin-1-one

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Reaction Steps

Example 40 was synthesized using the reaction sequence as described for the synthesis of Example 1. 240 mg of 4-(amino-phenyl-methyl)-cyclohexanol (123) and 272 mg of 7-chloro-6-fluoro-1-methoxy-isoquinoline (10) were used to give 51 mg of Example 40 as its hydrochloride. Rt=1.34 min (Method 10). Detected mass: 383.1 (M+H+). 28 mg of the other isomer of 4-(amino-phenyl-methyl)-cyclohexanol (Example 128) were also isolated as its hydrochloride. Rt=1.31 min (Method 10). Detected mass: 383.1 (M+H+). Separation of the two isomers was accomplished by silica gel chromatography after coupling of aminoalcohol 123 and 10. Relative stereochemistry was not assigned.

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