Hydrochloric Acid → (E)-[2-(6-Carboxy-4-methyl-2-propylbenzimidazol-1-yl)methyl-10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5-ylidene]acetonitrile

Participants

Reaction Steps

[step 2] (E)-[2-(6-Methoxycarbonyl-4-methyl-2-propylbenzimidazol-1-yl)methyl-10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5-ylidene]acetonitrile (500 mg, 1.05 mmol) obtained in step 1 was dissolved in ethanol (7.5 mL), 2 mol/L aqueous sodium hydroxide solution (2.5 mL) was added, and the mixture was stirred under reflux for 30 min. The mixture was adjusted to pH 2 with 2 mol/L hydrochloric acid, and the precipitated solid was collected by filtration to give the title compound (554 mg) quantitatively.

Provenance & Evidence