HuagongsheHuagongshe Chemistry Print Report · For research reference only
Benzene, 1-fluoro-2-methyl-4-nitro- → 3-({[tert-Butyl(diphenyl)silyl]oxy}methyl)-1-(2-methyl-4-nitrophenyl)pyridin-2(1H)-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Benzene, 1-fluoro-2-methyl-4-nitro- | HCID 68001 | — |
| Reactant | 3-({[tert-Butyl(diphenyl)silyl]oxy}methyl)pyridin-2(1H)-one | HCID 59410156 | — |
| Product | 3-({[tert-Butyl(diphenyl)silyl]oxy}methyl)-1-(2-methyl-4-nitrophenyl)pyridin-2(1H)-one | HCID 59410212 | — |
Reaction Steps
Analogously to Example 4A, 1.50 g (4.13 mmol) of the compound from Example 3A are reacted with 704 mg (4.54 mmol) of 2-fluoro-5-nitrotoluene. This gives 570 mg (28% of theory) of the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08487111B2 |
| Source dataset | uspto-grants-2013_07 |
| ORD ID | ord-4c3fcb9138094069976eb2434d353343 |
| Source note | uspto-grants-2013_07 |