1-Naphthaleneacetic Acid → HCID 44132436, compound

Participants

Reaction Steps

The title compound was prepared from Intermediate 10 (200 mg, 0.761 mmol) and 1-naphthylacetic acid (171 mg, 0.913 mmol) in presence of EDCI.HCl (221 mg, 1.141 mmol), HOBt (176 mg, 1.141 mmol) and triethylamine (317 μl, 2.283 mmol) in THF (5 ml) as described in Example 1 to give 250 mg of the product as a white solid; IR (KBr) 3236, 2945, 1638, 1412, 1223, 788 cm−1; 1H NMR (300 MHz, CDCl3) δ 1.47-1.55 (m, 2H), 1.72-1.78 (m, 2H), 2.09 (t, J=7.8 Hz, 3H), 2.16-2.26 (m, 1H), 4.09 (q, J=6.9 Hz, 2H), 5.11-5.19 (m, 1H), 5.29 (d, J=8.4 Hz, 1H), 6.55 (s, 2H), 6.66 (s, 1H), 7.35-7.42 (m, 2H), 7.49-7.59 (m, 2H), 7.77 (d, J=7.2 Hz, 1H), 7.82 (d, J=7.8 Hz, 1H), 7.98 (d, J=7.8 Hz, 1H); APCI-MS (m/z) 392.12 (M+H)+.

Provenance & Evidence