1-Naphthaleneacetic Acid → HCID 44132437, compound

Participants

Reaction Steps

The title compound was prepared from Intermediate 3 (100 mg, 0.448 mmol) and 1-naphthylacetic acid (99 mg, 0.531 mmol) in presence of EDCI.HCl (128 mg, 0.672 mmol), HOBt (102 mg, 0.672 mmol) and triethylamine (185 μl, 2.022 mmol) in dichloromethane (10 ml) as described in Example 1 to give 100 mg of the product as a white solid; IR (KBr) 3271, 2938, 1636, 1449, 1244, 778 cm−1; 1H NMR (300 MHz, CDCl3) δ 1.62-1.78 (m, 5H), 2.11-2.30 (m, 3H), 4.09 (q, J=16.8 Hz, 2H), 5.23 (q, J=9.3 Hz, 1H), 5.46 (d, J=7.8 Hz, 1H), 6.52 (t, J=7.2 Hz, 1H), 6.60 (d, J=7.2 Hz, 1H), 7.07 (d, J=7.8 Hz, 1H), 7.37-7.42 (m, 2H), 7.48-7.59 (m, 2H), 7.77 (t, J=6.3 Hz, 1H), 7.84 (d, J=7.8 Hz, 1H), 7.99 (d, J=8.1 Hz, 1H); ESI-MS (m/z) 392.59 (M+H)+.

Provenance & Evidence