HuagongsheHuagongshe Chemistry Print Report · For research reference only
HCID 58362636, compound → HCID 58362463, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | HCID 58362636 | HCID 58362636 | — |
| Reactant | HCID 58362708 | HCID 58362708 | — |
| Catalyst | Copper(1+) iodide; Copper(I) iodide; Cuprous iodide; Cuprous iodide (CuI) | HCID 24350 | — |
| Solvent | Acetonitrile | HCID 6342 | — |
| Product | HCID 58362463 | HCID 58362463 | — |
Reaction Steps
A 5 mL microwave tube is charged with 2 (1 equiv), 4-ethynyl-N-methyl-2-nitroaniline (1 equiv) [Pd(PPh3)4] (0.05 equiv), CuI (0.05 equiv) and TEA (5 equiv) in ACN (5 vol). The suspension is irradiated in a Biotage Emrys Optimizer microwave reactor (250 W) at 100° C. for 5 min. After cooling to room temperature, the solvent is evaporated in vacuo. The residue is purified over silica gel using Hexanes:DCM (0-100%) as the eluent to afford the coupling product.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08491869B2 |
| Source dataset | uspto-grants-2013_07 |
| ORD ID | ord-8ff5502b1f214eed9b6027eaee65bc6d |
| Source note | uspto-grants-2013_07 |