Trifluoroacetic acid → 4-(4-fluoroquinolin-2-yl)-N-methylaniline

Participants

Reaction Steps

tert-Butyl (4-(4-fluoroquinolin-2-yl)phenyl)(methyl)carbamate (4.5 mg, 0.013 mmol) was treated with TFA by using general procedure P. The crude product was purified by HPLC to afford T466 as an orange-colored solid (1.8 mg, 55%). 1H NMR (400 MHz, CDCl3): δ 8.57 (d, J=8.4 Hz, 1H), 8.02-7.97 (m, 3H), 7.75 (t, J=7.6 Hz, 1H), 7.56 (d, J=10.0 Hz, 1H), 6.72 (d, J=8.4 Hz, 2H), 2.95 (s, 3H); MS (ESI): 253 (M+H+).

Provenance & Evidence