Carbidopa → Levodopa

HRID 452339Notes

Reaction equation

HRID 452339 reaction equation
C[C@@:2]([NH:15]N)([C:12]([OH:14])=[O:13])[CH2:3][C:4]1[CH:5]=[CH:6][C:7]([OH:11])=[C:8]([OH:10])[CH:9]=1>C1C(CCN)=CC(O)=C(O)C=1>[CH:5]1[C:4]([CH2:3][C@H:2]([NH2:15])[C:12]([OH:14])=[O:13])=[CH:9][C:8]([OH:10])=[C:7]([OH:11])[CH:6]=1

Participants

3

Reactant 1

HCID 34359Carbidopa

Product 1

HCID 6047LevodopaYield 458.9%

Reagents, catalysts & solvents 1

HCID 681DopamineSolvent

Procedure

The in vitro dissolution profile of Sinemet® CR 50-200 tablets, containing 50 mg carbidopa and 200 mg levodopa were obtained under simulated gastric conditions. The dissolution tests were performed in 900 mL of a 0.1 N HCl-pH 1.2 solution, in a USP II apparatus at a temperature of 37° C. The paddle speed was set at 50 rpm. Samples of dissolution media were collected at predetermined intervals and analyzed by HPLC. The dissolution profiles of levodopa and carbidopa obtained from HPLC analysis are shown in FIG. 13.

Sources & evidence

ORD record
ord-7eda501e279141dfaef8fb528ff15526
Source dataset
uspto-grants-2013_07
Patent number
US08491929B2

Reaction notes

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