Potassium Carbonate → HCID 44481359, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of 2-(bromomethyl)-7-[(trifluoromethyl)sulfonyl]-4H-1,3-benzodioxine (0.40 g, 1.11 mmol), pyrrolidine (0.47 ml, 5.5 mmol), potassiumcarbonate (0.23 g, 1.7 mmol) and ACN (3.0 ml) was heated in a micro wave oven at 150° C. for 15 min. The mixture was filtered and evaporated to dryness. The residue was purified two times on a silica column using EtOAc/MeOH (4:1) and EtOAc/MeOH (9:1) as eluents. The pure fractions were collected and evaporated to afford the title product (0.19 g, 48%). The amine was converted into the fumaric acid salt and crystallized from EtOH/MeOH/DEE. M.p. 184° C. MS m/z (rel. intensity, 70 eV) 351 (M+, 5), 85 (6), 84 (bp), 76 (5), 55 (4).

Provenance & Evidence