Ethylamine → HCID 44481626, compound

Participants

Reaction Steps

Preparation according to Example 9. 2-(bromomethyl)-7-[(trifluoromethyl)sulfonyl]-4H-1,3-benzodioxine (0.28 g, 0.76 mmol), ethanamine (70% in water, 2.0 ml, 25.2 mmol) and ACN (2.0 ml) was heated at 120° C. for 20 min. Purification by flash chromatography using EtOAc/MeOH (4:1) as eluent afforded the title compound (0.14 g, 52%). The amine was converted into hydrochloric acid salt and crystallized from EtOH/DEE. M.p. 169° C. MS m/z (rel. intensity, 70 eV) 325 (M+, 1), 239 (5), 106 (5), 77 (7), 58 (bp).

Provenance & Evidence