Dipropylamine → N-{[5-Fluoro-7-(methylsulfonyl)-4H-1,3-benzodioxin-2-YL]methyl}-N-propylpropan-1-amine

HRID 452429Notes

Reaction equation

HRID 452429 reaction equation
Br[CH2:2][CH:3]1[O:8][C:7]2[CH:9]=[C:10]([S:14]([CH3:17])(=[O:16])=[O:15])[CH:11]=[C:12]([F:13])[C:6]=2[CH2:5][O:4]1.[CH2:18]([NH:21][CH2:22][CH2:23][CH3:24])[CH2:19][CH3:20]>CCO>[F:13][C:12]1[C:6]2[CH2:5][O:4][CH:3]([CH2:2][N:21]([CH2:22][CH2:23][CH3:24])[CH2:18][CH2:19][CH3:20])[O:8][C:7]=2[CH:9]=[C:10]([S:14]([CH3:17])(=[O:16])=[O:15])[CH:11]=1

Participants

4

Reactant 2

HCID 8902DipropylamineHCID 668876212-(bromomethyl)-5-fluoro-7-(methylsulfonyl)-4H-1,3-benzodioxine

Product 1

HCID 44482181N-{[5-Fluoro-7-(methylsulfonyl)-4H-1,3-benzodioxin-2-YL]methyl}-N-propylpropan-1-amine

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

Preparation according to Example 34 using 2-(bromomethyl)-5-fluoro-7-(methylsulfonyl)-4H-1,3-benzodioxine (7 mg, 0.021 mmol), N-propylpropan-1-amine (0.5 ml) and EtOH (3 ml). MS m/z (rel. intensity, 70 eV) 345 (M+, 0.3), 115 (9), 114 (bp), 95 (5), 86 (14), 72 (6).

Workup

  1. customPreparation

Sources & evidence

ORD record
ord-9237eff4650348fa94a89a86c25295af
Source dataset
uspto-grants-2013_07
Patent number
US08492372B2

Reaction notes

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