反应详情

In Parr apparatus, a mixture of 1 g (5.33 mmol) of methyl (2E)-3-(5-methoxypyridin-3-yl)prop-2-enoate in 20 mL of MeOH and 0.1 g of 10% Pd/C is hydrogenated at 7 bar for 5 hours. The reaction mixture is then filtered through Whatman GF/F paper and concentrated under reduced pressure. 1 g of methyl 3-(5-methoxypyridin-3-yl)propanoate is thus obtained in the form of a wax, which is used without further purification in the following step.

1. filtrationThe reaction mixture is then filtered through Whatman GF/F paper
2. concentrationconcentrated under reduced pressure