HuagongsheHuagongshe Chemistry Print Report · For research reference only
Dimethylamine → 1-[5-Fluoro-7-(methylsulfonyl)-4H-1,3-benzodioxin-2-YL]-N,N-dimethylmethanamine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Dimethylamine | HCID 674 | — |
| Reactant | 2-(bromomethyl)-5-fluoro-7-(methylsulfonyl)-4H-1,3-benzodioxine | HCID 66887621 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | 1-[5-Fluoro-7-(methylsulfonyl)-4H-1,3-benzodioxin-2-YL]-N,N-dimethylmethanamine | HCID 44482445 | — |
Reaction Steps
Preparation according to Example 34 using 2-(bromomethyl)-5-fluoro-7-(methylsulfonyl)-4H-1,3-benzodioxine (7 mg, 0.021 mmol), N-methylmethanamine (2.0 M in MeOH, 0.5 ml) and EtOH (3 ml). MS m/z (rel. intensity, 70 eV) 289 (M+, 0.2), 141 (2), 95 (4), 75 (5), 59 (4), 58 (bp).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08492372B2 |
| Source dataset | uspto-grants-2013_07 |
| ORD ID | ord-86c1c826f16c44cb9046b669d90b9055 |
| Source note | uspto-grants-2013_07 |