Ethanol → HCID 44482447, compound

HRID 452432Notes

Reaction equation

HRID 452432 reaction equation
Br[CH2:2][CH:3]1[O:8][C:7]2[CH:9]=[C:10]([S:14]([CH3:17])(=[O:16])=[O:15])[CH:11]=[C:12]([F:13])[C:6]=2[CH2:5][O:4]1.[CH3:18][CH:19]([NH2:21])[CH3:20].CCO>C(CC(C)(C)C)(C)C>[F:13][C:12]1[C:6]2[CH2:5][O:4][CH:3]([CH2:2][NH:21][CH:19]([CH3:20])[CH3:18])[O:8][C:7]=2[CH:9]=[C:10]([S:14]([CH3:17])(=[O:16])=[O:15])[CH:11]=1

Participants

5

Reactant 3

HCID 702EthanolHCID 6363IsopropylamineHCID 668876212-(bromomethyl)-5-fluoro-7-(methylsulfonyl)-4H-1,3-benzodioxine

Product 1

HCID 44482447HCID 44482447, compound

Reagents, catalysts & solvents 1

HCID 109072,2,4-TrimethylpentaneSolvent

Procedure

Preparation according to Example 34 using 2-(bromomethyl)-5-fluoro-7-(methylsulfonyl)-4H-1,3-benzodioxine (8.5 mg, 0.026 mmol), propan-2-amine (0.5 ml) and EtOH (3 ml). MS m/z (rel. intensity, 70 eV) 303 (M+, 0.3), 95 (10), 86 (14), 75 (8), 72 (bp), 58 (9).

Workup

  1. customPreparation

Sources & evidence

ORD record
ord-9caa1a12a64d45ca882f66f5b73288e1
Source dataset
uspto-grants-2013_07
Patent number
US08492372B2

Reaction notes

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