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A mixture of 43.5 g (214 mmol) of ethyl 3-cyano-3-phenylpropanoate and 52.2 g (930.4 mmol) of potassium hydroxide in 670 mL of EtOH is refluxed for 4 hours. After cooling to room temperature, the medium is concentrated under vacuum and then treated with 1 L of 1N HCl, and a precipitate then forms, which is filtered off and rinsed with water (2×50 mL). The solid obtained is taken up in a mixture of 200 mL of toluene and 40 mL of EtOH and concentrated under reduced pressure, and then dried with a vane pump. 37 g of 2-phenylbutanedioic acid are obtained in the form of a solid, which is used without further purification in the following step.

1. temperatureis refluxed for 4 hours
2. concentrationthe medium is concentrated under vacuum
3. additiontreated with 1 L of 1N HCl
4. filtrationwhich is filtered off
5. washrinsed with water (2×50 mL)
6. customThe solid obtained
7. concentrationconcentrated under reduced pressure
8. customdried with a vane pump