Sulfuric Acid → HCID 67155666, compound

Participants

Reaction Conditions

Reaction Steps

Preparation according to Preparation 9. 2-(hydroxymethyl)-5-[(trifluoromethyl)sulfonyl]phenol (2.7 g, 10.5 mmol), 2-bromo-1,1-dimethoxyethane (3.0 ml, 25.4 mmol), conc. H2SO4 (1.0 ml), THF (20 ml). Heating at 50° C. for 6 h. Additional 2-bromo-1,1-dimethoxyethane (5×0.5 ml, 21.1 mmol) and conc. H2SO4 (3×1.0 ml) were added during the reaction. Purification by flash column chromatography gave the title compound (3.3 g). MS m/z (rel. intensity, 70 eV) 362 (M+, 5), 360 (M+, 5), 267 (bp), 238 (64), 141 (52), 77 (55).

Provenance & Evidence