HuagongsheHuagongshe Chemistry Print Report · For research reference only
Boron tribromide → Methyl 4-bromo-5-fluoro-2-hydroxybenzoate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Boron tribromide | HCID 25134 | — |
| Reactant | Methyl 4-bromo-5-fluoro-2-methoxybenzoate | HCID 66886916 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | Methyl 4-bromo-5-fluoro-2-hydroxybenzoate | HCID 66887268 | — |
Reaction Steps
Preparation according to Preparation 7, using boron tribromide (1.0 M, 25.0 ml, 25.2 mmol) in DCM (25 ml) and methyl 4-bromo-5-fluoro-2-methoxybenzoate (2.2 g, 8.4 mmol) in DCM (15 ml). Yield: 2.1 g. MS m/z (rel. intensity, 70 eV) 250 (M+, 40), 248 (M+, 41), 218 (99), 216 (bp), 188 (41), 186 (41), 81 (39).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08492372B2 |
| Source dataset | uspto-grants-2013_07 |
| ORD ID | ord-0c523302cde245bab1c0a05f358288d4 |
| Source note | uspto-grants-2013_07 |