HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methyl 4-bromo-5-fluoro-2-hydroxybenzoate → 5-Bromo-4-fluoro-2-(hydroxymethyl)phenol
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methyl 4-bromo-5-fluoro-2-hydroxybenzoate | HCID 66887268 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | 5-Bromo-4-fluoro-2-(hydroxymethyl)phenol | HCID 67156027 | — |
Reaction Steps
Preparation according to Preparation 21, using methyl 4-bromo-5-fluoro-2-hydroxybenzoate (2.1 g, 8.4 mmol), borane tetrahydrofuran complex (31.0 ml, 31.0 mmol) and dry THF. Yield: 3.3 g (not pure). ESIMS: m/z 221 (M+H)+, 219 (M+H)+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08492372B2 |
| Source dataset | uspto-grants-2013_07 |
| ORD ID | ord-d440b9dd68c9435483e88b2a7a1d81b5 |
| Source note | uspto-grants-2013_07 |