HuagongsheHuagongshe Chemistry Print Report · For research reference only
Water → Diisopropyl Ether
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Water | HCID 962 | — |
| Reactant | Potassium Bicarbonate | HCID 516893 | — |
| Reactant | 1,3-Dichloro-5-(3,3,3-trifluoroprop-1-en-2-yl)benzene | HCID 23159823 | — |
| Reactant | Chloro-3-methyl-4-nitrobenzaldoxime | HCID 86667536 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | Diisopropyl Ether | HCID 7914 | — |
| Product | 5-(3,5-Dichlorophenyl)-3-(3-methyl-4-nitrophenyl)-5-trifluoromethyl-4,5-dihydroisoxazole | HCID 23159801 | — |
Reaction Steps
In a solution of 1.31 g of 3,5-dichloro-1-(1-trifluoromethylethenyl)benzene synthesized in Step 1 of Synthetic Example 3 and 1.17 g of -chloro-3-methyl-4-nitrobenzaldoxime in 10 ml of tetrahydrofuran, 1.15 g of potassium hydrogen carbonate and 1.50 g of water were added, and stirred at room temperature for 18 hours. After the completion of the reaction, tetrahydrofuran was removed from the reaction mixture, 3 ml of water was added, and stirred under colloing with ice for further 30 minutes. Precipitated crystal was filtered off, washed with 5 ml of water and then 5 ml of diisopropyl ether to obtain 1.29 g of the aimed product as white crystal.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08492311B2 |
| Source dataset | uspto-grants-2013_07 |
| ORD ID | ord-b1893f348bed46d68c4b793fc4e20740 |
| Source note | uspto-grants-2013_07 |