Triethylamine → HCID 178486164, compound

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Reaction Steps

To a solution of trans-8-chloro-1-[4-(3-fluoro-pyridin-2-yl)-cyclohexyl]-5,6-dihydro-4H-2,3,5,10b-tetraaza-benzo[e]azulene (50.0 mg, 0.126 mmol) and triethylamine (0.035 ml, 0.251 mmol) in dichloromethane (0.6 ml) was added dimethyl sulfamoyl chloride (0.27 ml, 0.251 mmol) at room temperature. Stirring for 20 h was followed by quenching with methanol (0.5 ml). The mixture was concentrated in vacuo. Preparative RP-HPLC with water (0.05% formic acid)/methanol as eluent gave the title compound (39 mg, 61%) as white solid. MS m/e: 505 ([M+H]+)

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