Benzaldehyde → HCID 44218795, compound

Participants

Reaction Steps

To a solution of 4-{(1S)-1-(4-methoxylphenyl)-2-[4-(trifluoromethyl)phenyl]ethyl}-1H-imidazole-2-amine (0.05 g, 0.14 mmol) in H2O (1 mL) and THF (0.5 mL) was added benzaldehyde (0.018 g, 0.17 mmol) and sodium carbonate (0.01 g, 0.08 mmol). The reaction was stirred at room temperature for 12 h. The reaction was concentrated and purified by RP HPLC to provide (2-amino-4-{(1S)-1-(4-methoxyphenyl)-2-[4-(trifluoromethyl)phenyl]ethyl}-1H-imidazole-5-yl) (phenyl)methanol (0.01 g, 14%).

Provenance & Evidence