Acetyl chloride → HCID 68664228, compound

Participants

Reaction Steps

To a solution of 3-(4-methoxyphenyl)-1-benzofuran-5-carbohydrazide (565 mg, 2.00 mmol) and triethylamine (0.418 mL, 3.00 mmol) in tetrahydrofuran (30 mL) was added acetyl chloride (0.213 mL, 3.00 mmol) at room temperature, and the resulting mixture was stirred for 30 min. The reaction mixture was diluted with ethyl acetate, washed with saturated brine, dried over anhydrous magnesium sulfate and concentrated under reduced pressure. The residue was washed with hexane/ethyl acetate (1/1) to give the title compound (613 mg, yield 94%) as colorless crystals.

Provenance & Evidence